Published: Dec 15, 2016
  
 
     
 
Tranexamic acid Total Knee Arthroplasty Total hip Arthroplasty
  
     
 
   
 
 
 
 
 
 
 
 
 
 
 

 

 
   
 
 
 
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    Home / Archives / Vol. 13 No.1 (2017): JAN - JUN / Original Article  
 
   
 

The use of intravenous tranexamic acid for reduction of blood loss in total knee and hip arthroplasty.
   
 
   
   
     
 
ประมุข วนัสบดีกุล
Orthopaedic unit, Priest hospital, Bangkok

Abstract

Objective: To evaluate the effect of intravenous tranexamic acid on blood loss and packed red cell transfusion requirements in total knee arthroplasty (TKA) and total hip arthroplasty (THA) in Thai patients.


Methods: This study evaluates the use of TXA in 40 TKA and 40 THA performed in a single surgeon between 2011 and 2015. The initial 20 patients of both groups (TKA and THA) underwent surgery without TXA (no TXA group) while the subsequent 20 patients all received 1 g TXA (TXA group). Perioperative blood loss, postoperative blood loss, total blood loss, postoperative 24hr Hct, total PRC transfusion, and deep vein thrombosis (DVT) were examined.


Results: In both TKA and THA, total blood loss were significantly higher in the no TXA group (TKA: 520 cc vs 395 cc ; P-value 0.019 and THA: 1,445 cc vs 950 cc ; P-value 0.001). Postoperative 24hr Hct were lower in no TXA group in both TKA and THA, but only significant in TKA (TKA: 29.8 ± 3.1 กับ 33.6 ± 3.7; P-value 0.001 และ THA: 30.9 ± 3.3 กับ 31.3 ± 3.7; P-value 0.283). Total PRC transfusion were higher significantly in the no TXA group (TKA: 16 units vs 2 units ; P-value 0.001 และ THA: 48 units vs 11 units ; P-value 0.005). None of the patients developed DVT.


Conclusion: Intravenous TXA can significantly reduce total blood loss and total PRC transfusion in both TKA and THA without significant increase in postoperative DVT.


Key words:  Tranexamic acid, Total Knee Arthroplasty, Total hip Arthroplasty

  
     
     
 
    How to Cite  
     
  วนัสบดีกุล ป. (2016). The use of intravenous tranexamic acid for reduction of blood loss in total knee and hip arthroplasty. Journal of Charoenkrung Pracharak Hospital, 13(1), 1–10. Retrieved from https://he02.tci-thaijo.org/index.php/JCP/article/view/178446  
     

 
 
     
     
 
    Issue  
     
  Vol. 13 No.1 (2017): JAN - JUN  

 
 
     
     
 
    Section  
     
  Original Article  

 
 
     
     
     
 

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